Publications

  1. Jiang Q.K.#, Su K.#, Luo H., Wang H., Luo J., Zhong Y.J., Li Q., Zhang Z., Zhang H., He B., Zhang L., Li Q., Ma L.X., Cui H., Ma J., Yang X., Li L., Yuan Z., Liu S., and Li, X.  (2025) Modular mRNA lipid nanoparticle platform rescues diverse genetic male infertility. bioRxiv. doi: https://doi.org/10.1101/2025.11.13.688269

  2. Zhang C.K., and Li, X.  (2025) DNA damage hypersensitivity in chicken primordial germ cells limits CRISPR-Cas9 editing and supports an shRNA-based screening approach. bioRxiv. doi: https://doi.org/10.1101/2025.09.17.676926

  3. Xu, M.M., and Li, X.Z. (2024) Enigmatic Pachytene PIWI-Interacting RNAs. Genome Biology and Evolution. 16(10)

  4. Sun, Y.H., Cui, H., Song, C., Shen, J.T., Wang, Y.R., Yu, X., Zhuo, X., Ndamba, R., Mu Q., Gu, H., Wang, D., Murthy, G.G., Li, Pi., Liang, F., Liu, L., Tao, Q., Wang, Y., Orlowski, S., Zhou, H., Jagne, J., Gokcumen, O., Anthony, N. Zhao, X, and Li, X.Z. (2023) Amniotes co-opt intrinsic genetic instability to protect germ-line genome integrity. Nature Communications. 14(1):812

  5. Yin Q., Yang C. H., Strelkova O. S., Wu J., Sun, Y.H., Gopalan, S., Yang L., Dekker J., Fazzio T.G., Li, X.Z. , Gibcus J., Rando O. J. (2023). Revisiting chromatin packaging in mouse sperm. Genome Research, 33(12):2079–2093.

  6. Sun, Y.H., Wang, Y.R., Du, K, Y.H., and Li, X.Z. (2021) The birth of piRNAs: How mammalian piRNAs are produced, originated, and evolved. Mammalian Genome. 33(2):293

  7. Yu, Y.H., Wang, Y.R., Du, K., Zheng, J., Xie, L.H., Pereira A., Zhang, C., Ricci, E.P., and Li, X.Z. (2021) Coupled protein synthesis and ribosome-guided piRNA processing on mRNAs. Nature Communications. 12(1): 5970

  8. Sun, Y.H., Wang, A., Song, C., Srivastava, R.K., Au, K.F., Li, X.Z. (2021) Single-molecule long-read sequencing reveals a conserved intact long RNA profile in sperm. Nature Communications. 12(1):1361 (Highlighted in News and Views, Biol Reprod. 2021 Mar 31; ioab055)

  9. Gu, H., Yu, Y.H., Li, X.Z. (2021) Novel rRNA-depletion methods for total RNA sequencing and ribosome profiling developed for avian species. Poultry Science. 100:101321

  10. Avidor-Reiss, T., Zhang, Z., Li, X.Z. (2020) Sperm differentiation and spermatozoa function: mechanisms, diagnostics, and treatment. Frontiers in Cell and Developmental Biology; 8:219

  11. Sun, Y.H., Zhu, J., Xie, L.H., Li, Z., Zhu, X., Song, C. Chen, C., Ricci, E.P., Weng, Z., and Li, X.Z. (2020) Ribosomes guide pachytene piRNA formation on long intergenic piRNA precursors. Nature Cell Biology. 22, 200-212 (Highlighted in News and Views, Nature Cell Biology, 22,141-142, 2020)

  12. Li, X.Z. (2019) What can piRNA research learn from chickens, and vice versa? Canadian Journal of Animal Science. 99: 641–648

  13. Sun, Y.H., Jiang F., Li, X.Z. (2018) Disruption of Tdrd5 decouples the stepwise processing of long precursor transcripts during pachytene piRNA biogenesis. Biology of Reproduction, 99(4):684-685

  14. Sun, Y.H., Xie, L.H., Zhuo, X., Chen, Q., Ghoneim, D., Zhang, B., Jagne, J., Yang, C., Li, X.Z. (2017) Domestic chickens activate a piRNA defense against avian leukosis virus. eLife,6:e24695

  15. Sharma, U., Conine, C.C., Shea, JM., Boskovic, A., Derr, A.G., Bing, X.Y., Belleannee, C., Kucukural, A., Serra, RW., Sun, F., Song, L., Carone, B.R., Ricci, EP., Li, X.Z., Fauquier, L., Moore, M.J., Sullivan, R., Mello, C.C., Garber, M., Rando, O.J. (2016) Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals. Science, 351(6271): 391-396

  16. Ishiguro, K., Kim, J., Shibuya, H., Hernández-Hernández, A., Suzuki, A., Fukagawa, T., Shioi, G., Kiyonari, H., Li, X.C., Schimenti, J., Höög, C., and Watanabe Y. (2014) Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes. Genes & Development, 28(6):594-607

  17. Moran, Y., Fredman, D., Praher D., Li, X.Z., Wee, L., Rentzsch, F., Zamore, P.D., Technau, U. and Seitz, H. (2014) Cnidarian microRNAs frequently regulate targets by cleavage. Genome Research, 24(4):651-63

  18. Li, X.Z., Roy, C.K., Moore, M.J., and Zamore, P.D. (2013) Defining piRNA primary transcripts. Cell Cycle, 12:1657-8

  19. Li, X.Z., Roy, C.K., Dong, X., Bolcun-Filas, E.M., Wang, J., Han, B.W., Xu, J., Moore, M.J., Schimenti, J.C., Weng Z., and Zamore, P.D. (2013) An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes. Molecular Cell, 50: 67-81  (Highlighted in Nature Review Genetics, Nature, 14: 301, 2013)

  20. Li, X.C. Bolcun-Filas, E.M. and Schimenti, J.C. (2011) Genetic evidence that synaptonemal complex axial elements govern recombination partner choice in mice. Genetics, 189: 71-82

  21. Li, X.C. and Tye, B.K. (2011) Ploidy dictates repair pathway choice under DNA replication stress. Genetics, 187: 1031-40

  22. Li, X.C., Schimenti, J.C. and Tye, B.K. (2009) Aneuploidy and improved growth are coincident but not causal in a yeast cancer model. PLoS Biology l 7: e1000161

  23. Li, X.C., Barringer, B.C. and Barbash, D.A. (2008) The pachytene checkpoint and its relationship to evolutionary patterns of polyploidization and hybrid sterility. Heredity 9: 1-7

  24. Li, X.C. and Schimenti, J.C. (2007) Mouse pachytene checkpoint 2 (Trip13) is required for completing meiotic recombination but not synapsis. PLoS Genetics 3: 1785-1785

  25. Chen, F., Chen, Y., Dong, Y., Li, X., Xu, M., Zhang, C., Yan, Y., and Zhang, G. (2005) OsDof28, a new member of the DOF transcription factor family from rice. Tsinghua Science and Technology 10: 454-460

  26. Li, X., Jia, S., Jian, J., Lin, M., Li, Q., Huang, X., Zhang, C., Zhang, R., and Zhang, G. (2003) Physiological defense mechanism of Ligularia intermedia against UV-B radiation on Dongling Mountain. Tsinghua Science and Technology 8: 481-486
English